Histamine receptor antagonism does not inhibit hypoxic pulmonary vasoconstriction in dogs.
نویسندگان
چکیده
CHEST 71: 2, FEBRUARY, 1977 SUPPLEMENT 19TH ASPEN LUNG CONFERENCE 261 2 Kadowitz PJ, Joiner PD, Hyman AL: Physiological and pharmacological roles of prostaglandins. Ann Rev Pharmacol 15:285-306, 1975 3 Hamberg M, Samuelsson B: Prostaglandin endopero,ddes. VII. Novel transformations of arachidonic acid in guinea pig lung. Biocheni Biophys Res Commun 61:942-949, 1974 4 Hamberg M, !Iedqvist P. Strandberg K, et al: Prostaglandin endoperoxides. IV. Effects on smooth muscle. Life Sci 16:451-462, 1975
منابع مشابه
Sustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
متن کاملEndogenous endothelins and nitric oxide in hypoxic pulmonary vasoconstriction.
The effects of endothelin receptor blockade on the pulmonary circulation have been reported variably, possibly in relation to a more or less important associated release of endogenous nitric oxide (NO). The aim of this study was to test whether endothelin antagonism would inhibit hypoxic pulmonary vasoconstriction, and if it would not, then would it do so after NO synthase inhibition. Hypoxic p...
متن کاملAcute hypoxic pulmonary vasoconstriction in conscious dogs decreases renin and is unaffected by losartan.
Acute hypoxic pulmonary vasoconstriction (HPV) may be mediated by vasoactive peptides. We studied eight conscious, chronically tracheostomized dogs kept on a standardized dietary sodium intake. Normoxia (40 min) was followed by hypoxia (40 min, breathing 10% oxygen, arterial oxygen pressures 36 +/- 1 Torr) during both control (Con) and losartan experiments (Los; iv infusion of 100 microg. min-1...
متن کاملThe Interaction between Trolox and 4,4’-diisothiocyanatostilbene-2,2’-disulfonic Acid on Hypoxic Pulmonary Vasoconstriction in the Isolated Rabbit Lung
Background: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion ex...
متن کاملEndogenous angiotensin II in the regulation of hypoxic pulmonary vasoconstriction in anaesthetized dogs
INTRODUCTION The role played by several vasoactive mediators that are synthesized and released by the pulmonary vascular endothelium in the regulation of hypoxic pulmonary vasoconstriction (HPV) remains unclear. As a potent vasoconstrictor, angiotensin II could be involved. We tested the hypothesis that angiotensin-converting enzyme inhibition by enalaprilat and type 1 angiotensin II receptor b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Chest
دوره 71 2 suppl شماره
صفحات -
تاریخ انتشار 1977